Gene Expression Therapy

XPRIZE Healthspan poster for Minicircle gene therapy: Unlock the power of your genes

Gene Expression Therapy

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Selected from more than 600 teams across 58 countries, our gene therapy was named a Top 40 XPRIZE Healthspan Milestone winner for its potential to advance healthier aging.

Why Gene Expression Therapy?

Instead of treating symptoms, gene expression therapy helps your cells produce proteins your body naturally relies on for performance, recovery and healthy aging.

Non-Viral DNA Technology

No Permanent Genetic Changes

No Surgery or Downtime

Designed to Last Approximately
One Year

Available Gene Expression Therapies

House of Evolution currently provides access to two gene expression therapies, each targeting a different aspect of human performance and healthy aging.

Minicircle Follistatin gene therapy box

Follistatin

Improve your strength, recover faster and perform better.

Observed Outcomes:
Increase lean mass
Reduce body fat percentage
Lower epigenetic age
Improve overall wellbeing
0
serious adverse
events
-0.18%
bodyfat
% change
2lbs.
lean mass
increase
12yrs.
Epigenetic age reduction in older patients*
* measured via TruDiagnostic
Learn More
Minicircle Klotho gene therapy box

Klotho *Coming Soon

Gain a sharper edge against aging.

Anticipated Benefits:
Cognitive function
Healthy aging
Cardiovascular health
Kidney health
Learn More

Upcoming Dates

Gene Therapy

Cancún, Mexico
January I 16-17 I 2027
Apply for Access

Gene Therapy

Quito, Ecuador
February I 20-21 I 2027
Apply for Access

Gene Therapy

Puerto Vallarta, Mexico
March I 6-7 I 2027
Apply for Access

Gene Therapy

Liberia, Costa Rica
June I 19-20 I 2027
Apply for Access

How Gene Expression Therapy Works

Illustration of a subcutaneous injection into bunched skin

1
Simple Outpatient Injection

Treatment is administered through a simple subcutaneous injection by licensed medical professionals. The procedure typically takes less than an hour, requires no surgery and involves no downtime.

Illustration of a DNA plasmid combining with a delivery molecule

2
Temporary Instructions for Your Cells

A non-viral DNA plasmid delivers a temporary set of genetic instructions to your cells. Because these instructions remain outside your chromosomes, they do not permanently alter your DNA.

Illustration of a plasmid inside a cell producing proteins

3
Your Cells Do
the Work

Your cells begin producing beneficial proteins associated with strength, cognition and healthy aging. As your cells naturally renew over time, the temporary instructions fade, making the therapy repeatable.

See Gene Expression Therapy in Action

Watch how House of Evolution members experience gene expression therapy, from consultation to treatment, with licensed medical professionals.

Marc Kielburger talks about gene expression therapy, video cover

Explore the Science

Every therapy available through House of Evolution is supported by published research and ongoing clinical investigation.

Cover page of the Klotho and Follistatin study

Klotho &
Follistatin

2026 Preliminary Findings

Read Study
Cover page of the Follistatin gene expression therapy study

Follistatin Gene Expression Therapy

One-Year Human Study

Read Study
Cover page of the body composition and epigenetic age study

Body Composition & Epigenetic Age Study

Read Study

The Future of Human Performance
Is Already Here

Apply for Access

Frequently Asked Questions

How is gene expression therapy administered?

Through a simple subcutaneous injection administered by licensed medical professionals.

Does it permanently change my DNA?

No. The therapy uses non-viral DNA technology that remains outside your chromosomes and does not permanently alter your genetic code.

How long does it last?

Effects are designed to last approximately one year, after which treatment may be repeated if appropriate.

Is there downtime?

No. The procedure typically takes less than an hour, and there is no recovery period.